Semaglutide
GLP-1 Receptor AgonistBrand: Wegovy / Ozempic
Method: Weekly injection
Semaglutide is a GLP-1 receptor agonist that works by mimicking the hormone GLP-1, which targets areas of the brain that regulate appetite and food intake. It helps you feel fuller longer, reduces cravings, and slows gastric emptying.
- FDA-approved for chronic weight management
- Once-weekly subcutaneous injection
- Clinically proven in large-scale trials
- Gradual dose escalation over 16-20 weeks
- Works best combined with lifestyle changes
Average weight loss
Up to 15% body weight
Results vary by individual
Tirzepatide
GLP-1/GIP Dual AgonistBrand: Mounjaro / Zepbound
Method: Weekly injection
Tirzepatide is a first-in-class dual GIP and GLP-1 receptor agonist. It targets two incretin hormones simultaneously, providing enhanced blood sugar control and significant weight loss effects. Clinical trials have shown it to be one of the most effective weight loss medications available.
- Dual-action mechanism (GLP-1 + GIP)
- Once-weekly subcutaneous injection
- Shown to be more effective than semaglutide in head-to-head trials
- FDA-approved for type 2 diabetes and weight management
- Dose escalation over 20+ weeks
Average weight loss
Up to 22% body weight
Results vary by individual
Oral Semaglutide
GLP-1 Receptor Agonist (Oral)Brand: Rybelsus
Method: Daily tablet
Oral semaglutide provides the same mechanism as injectable semaglutide but in a convenient daily pill form. Ideal for patients who prefer not to self-inject. Taken once daily on an empty stomach, at least 30 minutes before eating.
- No injections required — daily oral tablet
- Same active ingredient as Wegovy/Ozempic
- Taken first thing in the morning on empty stomach
- Gradual dose increase for tolerability
- Good option for injection-averse patients
Average weight loss
Up to 10% body weight
Results vary by individual
Metformin
BiguanideBrand: Glucophage
Method: Daily tablet
Metformin is a well-established medication primarily used for type 2 diabetes that also supports weight management. It works by reducing glucose production in the liver, improving insulin sensitivity, and may modestly reduce appetite.
- Decades of safety data
- Oral tablet taken 1-2 times daily
- May be combined with GLP-1 medications
- Very affordable generic medication
- Additional cardiovascular benefits
Average weight loss
Up to 5% body weight
Results vary by individual
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